Strain-Specific Altered Regulatory Response of Rab7a and Tau in Creutzfeldt-Jakob Disease and Alzheimer's Disease

Zafar S, Younas N, Correia S, Shafiq M, Tahir W, Schmitz M, Ferrer I, Andréoletti O, Zerr I.

Mol Neurobiol. 2016 Jan 14. [Epub ahead of print]

open Pubmed abstract

Targeting intrinsically disordered proteins in rational drug discovery

Ambadipudi S, Zweckstetter M.

Expert Opin Drug Discov. 2016 Jan;11(1):65-77. doi: 10.1517/17460441.2016.1107041. Epub 2015 Nov 7

open Pubmed abstract

DNA methylation changes in plasticity genes accompany the formation and maintenance of memory

Halder R, Hennion M, Vidal RO, Shomroni O, Rahman RU, Rajput A, Centeno TP, van Bebber F, Capece V, Vizcaino JC, Schuetz AL, Burkhardt S, Benito E, Sala MN, Javan SB, Haass C, Schmid B, Fischer A, Bonn S.

Nat Neurosci. 2016 Jan;19(1):102-10. doi: 10.1038/nn.4194. Epub 2015 Dec 14.

open pubmed abstract

Application of capillary immunoelectrophoresis revealed an age- and gender-dependent regulated expression of PrPC in liver

Arora AS, Zafar S, Kollmar O, Llorens F, Tahir W, Vanselow S, Kumar P, Schmerr MJ, Schmitz M, Zerr I.

Electrophoresis. 2015 Dec;36(24):3026-33. doi: 10.1002/elps.201500244. Epub 2015 Nov 9.

open Pubmed abstract

The physiological concentration of ferrous iron (II) alters the inhibitory effect of hydrogen peroxide on CD45, LAR and PTP1B phosphatases

Kuban-Jankowska A, Gorska M, Jaremko L, Jaremko M, Tuszynski JA, Wozniak M.

Biometals. 2015 Dec;28(6):975-86. doi: 10.1007/s10534-015-9882-4. Epub 2015 Sep 25.

open Pubmed abstract

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development

Narayanan R, Pirouz M, Kerimoglu C, Pham L, Wagener RJ, Kiszka KA, Rosenbusch J, Seong RH, Kessel M, Fischer A, Stoykova A, Staiger JF, Tuoc T.

Cell Rep. 2015 Dec 1;13(9):1842-54. doi: 10.1016/j.celrep.2015.10.046. Epub 2015 Nov 19.

open Pubmed abstract

Environmental enrichment as a method to improve cognitive function. What can we learn from animal models?

Fischer A.

Neuroimage. 2015 Nov 30. pii: S1053-8119(15)01061-7. doi: 10.1016/j.neuroimage.2015.11.039. [Epub ahead of print]

open Pubmed abstract

Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes

Stepniak B, Kästner A, Poggi G, Mitjans M, Begemann M, Hartmann A, Van der Auwera S, Sananbenesi F, Krueger-Burg D, Matuszko G, Brosi C, Homuth G, Völzke H, Benseler F, Bagni C, Fischer U, Dityatev A, Grabe HJ, Rujescu D, Fischer A, Ehrenreich H.

EMBO Mol Med. 2015 Nov 26;7(12):1565-79. doi: 10.15252/emmm.201505696.

open Pubmed abstract

Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cells

Moree B, Yin G, Lázaro DF, Munari F, Strohäker T, Giller K, Becker S, Outeiro TF, Zweckstetter M, Salafsky J.

J Biol Chem. 2015 Nov 13;290(46):27582-93. doi: 10.1074/jbc.M114.636027. Epub 2015 Sep 22.

open Pubmed abstract

Structural ensembles of intrinsically disordered proteins depend strongly on force field: A comparison to experiment

Rauscher S, Gapsys V, Gajda MJ, Zweckstetter M, de Groot BL, Grubmüller H.

J Chem Theory Comput. 2015 Nov 10;11(11):5513-24. doi: 10.1021/acs.jctc.5b00736. Epub 2015 Oct 22.

open Pubmed abstract

Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings

Gapsys V, Narayanan RL, Xiang S, de Groot BL, Zweckstetter M.

J Biomol NMR. 2015 Nov;63(3):299-307. doi: 10.1007/s10858-015-9990-z. Epub 2015 Oct 3.

open Pubmed abstract

Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand.

Jaremko M, Jaremko Ł, Giller K, Becker S, Zweckstetter M.

Biomol NMR Assign. 2016 Apr;10(1):79-83. doi: 10.1007/s12104-015-9642-y. Epub 2015 Sep 12.

open Pubmed abstract

The Quest for Simplicity: Remarks on the Free-Approach Models.

Jaremko Ł, Jaremko M, Nowakowski M, Ejchart A.

J Phys Chem B. 2015 Sep 10;119(36):11978-87. doi: 10.1021/acs.jpcb.5b07181. Epub 2015 Aug 28.

open Pubmed abstract

HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models.

Benito E, Urbanke H, Ramachandran B, Barth J, Halder R, Awasthi A, Jain G, Capece V, Burkhardt S, Navarro-Sala M, Nagarajan S, Schütz AL, Johnsen SA, Bonn S, Lührmann R, Dean C, Fischer A.

J Clin Invest. 2015 Sep;125(9):3572-84. doi: 10.1172/JCI79942. Epub 2015 Aug 17.

open Pubmed abstract

Baseline CSF/Serum-Ratio of Apolipoprotein E and Rate of Differential Decline in Alzheimer's Disease.

Schmidt C, Gerlach N, Schmitz M, Thom T, Kramer K, Friede T, Zerr I.

J Alzheimers Dis. 2015;48(1):189-96. doi: 10.3233/JAD-150286.

open PubMed abstract

Folding of the Tau Protein on Microtubules

Kadavath H, Jaremko M, Jaremko Ł, Biernat J, Mandelkow E, Zweckstetter M.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10347-51. doi: 10.1002/anie.201501714. Epub 2015 Jun 19.

open Pubmed Abstract

Structural Impact of Tau Phosphorylation at Threonine 231

Schwalbe M, Kadavath H, Biernat J, Ozenne V, Blackledge M, Mandelkow E, Zweckstetter M.

Structure. 2015 Aug 4;23(8):1448-58. doi: 10.1016/j.str.2015.06.002. Epub 2015 Jul 9.

open Pubmed Abstract

Detection and Differentiation of Threonine- and Tyrosine-Monophosphorylated Forms of ERK1/2 by Capillary Isoelectric Focusing-Immunoassay

Kraus I, Besong Agbo D, Otto M, Wiltfang J, Klafki H.

Sci Rep. 2015 Aug 3;5:12767. doi: 10.1038/srep12767.

open Pubmed Abstract

Structure of the mammalian TSPO/PBR protein

Jaremko M, Jaremko Ł, Jaipuria G, Becker S, Zweckstetter M.

Biochem Soc Trans. 2015 Aug;43(4):566-71. doi: 10.1042/BST20150029. Epub 2015 Aug 3. Review.

open Pubmed abstract

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki JE, Zweckstetter M, Dickey CA.

Hum Mol Genet. 2015 Jul 15;24(14):3971-81. doi: 10.1093/hmg/ddv135. Epub 2015 Apr 16.

PMID: 25882706

open Pubmed Abstract

Involvement of PrP C in kainate-induced excitotoxicity in several mouse strains

Carulla P, Llorens F, Matamoros-Angles A, Aguilar-Calvo P, Espinosa JC, Gavín R, Ferrer I, Legname G, Torres JM, Del Río JA.

Sci Rep. 2015 Jul 9;5:11971. doi: 10.1038/srep11971.

PMID: 26155834

open Pubmed Abstract

Structural Integrity of the A147T Polymorph of Mammalian TSPO

Jaremko M, Jaremko Ł, Giller K, Becker S, Zweckstetter M.

Chembiochem. 2015 Jul 6;16(10):1483-9. doi: 10.1002/cbic.201500217. Epub 2015 Jun 10.

PMID: 25974690

open Pubmed Abstract

Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides

Cal M, Kotynia A, Jaremko Ł, Jaremko M, Lisowski M, Cebo M, Brasuń J, Stefanowicz P.

Dalton Trans. 2015 Jun 28;44(24):11172-81. doi: 10.1039/c5dt01267h. Epub 2015 May 26.

PMID: 26008716

open Pubmed Abstract

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

Kadavath H, Hofele RV, Biernat J, Kumar S, Tepper K, Urlaub H, Mandelkow E, Zweckstetter M.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7501-6. doi: 10.1073/pnas.1504081112. Epub 2015 Jun 1.

PMID: 26034266

open Pubmed Abstract

Cytokine profiles and the role of cellular prion protein in patients with vascular dementia and vascular encephalopathy

Schmitz M, Hermann P, Oikonomou P, Stoeck K, Ebert E, Poliakova T, Schmidt C, Llorens F, Zafar S, Zerr I.

Neurobiol Aging. 2015 Sep;36(9):2597-606. doi: 10.1016/j.neurobiolaging.2015.05.013. Epub 2015 Jun 11.

open Pubmed Abstract

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